The effect of temperature on the pulsed current processing behaviour and structural characteristics of porous ZSM-5 and zeolite Y monoliths

Hierachically porous monoliths of ZSM-5 and Y zeolites have been prepared by pulsed current processing (PCP). The densification behaviour and structural characteristics during rapid thermal treatment of the zeolites have been determined and related to the influence of the Si:Al ratio on the thermal stability of the zeolites. Monoliths of macroscopic shape can be prepared with an insignificant loss of surface area and micropore volume when the PCP-treatment was performed at temperatures below a critical maximum PCP temperature (T_PCP). Full-profile fittings of the powder X-ray diffraction patterns showed that the lattice strain of zeolite Y increases rapidly above the critical T_PCP while the ZSM-5 zeolites undergo a phase transition from orthorhombic to monoclinic. The use of a novel ceramic processing route for the production of the zeolite monoliths that do not significantly influence the structural characteristics and surface area of the starting materials has a potential to be of importance in catalysis and gas separation applications.     

Atorvastatin: an effective lipid-modifying agent in familial hypercholesterolemia

Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are the drugs of choice in heterozygous familial hypercholesterolemia (FH), which has a high risk of ischemic heart disease. An open-label study was conducted to test the efficacy and safety of atorvastatin, a new synthetic HMG-CoA reductase inhibitor in proven FH. After a 4-week placebo phase, 22 subjects were randomized to either 80 mg atorvastatin at night (n = 11) or 40 mg twice a day for 6 weeks. The two dosage groups were well matched and had no difference in lipoprotein responses. After 6 weeks, the LDL cholesterol concentration was reduced by 57%, from 8.16 +/- 1.15 to 3.53 +/- 0.99 mmol/L (P < .001). The total cholesterol concentration decreased from 9.90 +/- 1.32 to 5.43 mmol/L (P < .001). HDL cholesterol concentration increased from 1.19 +/- 0.31 to 1.49 +/- 0.43 mmol/L (P < .001). Triglyceride concentrations decreased from 1.34 +/- 0.66 to 0.88 +/- 0.36 mmol/L (P < .01). Three subjects had single, transient increases of serum transaminase of up to twice the upper limit of normal. Apolipoprotein B concentration decreased significantly by 42%. Changes in apolipoproteins AI and (a) were not statistically significant. Nondenaturing gradient gel electrophoresis revealed increases in the size of smaller LDL particles in four subjects. Plasma fibrinogen concentration increased by 44%. The drug was well tolerated. One subject withdrew for personal reasons. Atorvastatin is a powerful and safe lipid-modifying agent for LDL cholesterol; it also modifies HDL cholesterol and triglyceride concentrations, and may suffice as a single agent for many subjects with heterozygous FH.     

Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells

We studied the cell kill induced by granulocyte-macrophage colony-stimulating factor (GM-CSF ) fused to Diphtheria Toxin (DT-GM-CSF ) in acute myeloid leukemia (AML) samples and in populations of normal primitive hemopoietic progenitor cells. AML samples from three patients were incubated in vitro with 100 ng/mL DT-GM-CSF for 48 hours, and AML cell kill was determined in a proliferation assay, a clonogenic assay colony-forming unit-AML (CFU-AML) and a quantitative long-term bone marrow (BM) culture ie, the leukemic-cobblestone area forming cell assay (L-CAFC). To measure an effect on cells with in vivo leukemia initiating potential DT-GM-CSF exposed AML cells were transplanted into immunodeficient mice. In two out of three samples it was shown that all AML subsets, including those with long-term abilities in vivo (severe combined immunodeficient mice) and in vitro (L-CAFC assay) were reduced in number by DT-GM-CSF. Cell kill induced by DT-GM-CSF could be prevented by coincubation with an excess of GM-CSF, demonstrating that sensitivity to DT-GM-CSF is specifically mediated by the GM-CSF receptor. Therefore, binding and internalization of GM-CSF probably occur in immature AML precursors of these two cases of AML. The third AML sample was not responsive to either GM-CSF or DT-GM-CSF. The number of committed progenitors of normal bone marrow (burst-forming unit-erythroid, colony-forming unit granulocyte- macrophage, and cobble stone area forming cell [CAFC] week 2) and also the number of cells with long-term repopulating ability, assayed as week 6 CAFC, were unchanged after exposure to DT-GM-CSF (100 ng/mL, 48 hours). These studies show that DT-GM-CSF may be used to eliminate myeloid leukemic cells with long-term potential in vitro and in immunodeficient mice, whereas normal hemopoietic stem cells are spared.     

Density Measurements of Single Granules Using the Atomic Force Microscope

The density of single spray-dried granules has been determined with a new method based on atomic force microscopy (AFM). Spherical granules with a well-defined diameter are attached to the AFM cantilever, which acts as a beam-type spring, and the mass of a granule is estimated from the shift in the resonant frequency. The error of the measurements associated with the method was estimated to vary between 1% and 5%, depending on the size and shape of the granule. Density measurements of spray-dried WC–Co granules are presented, and the effect of a polymeric binder and dispersant on the consolidation during drying is discussed.     

Characterization of Scattering Parameters Near a Flat Phantom for Wireless Body Area Networks

In this paper, the scattering parameters of two dipoles placed closely to a flat, homogeneous, biological tissue are characterized in the 2.4-GHz band. The impact of the presence of a flat phantom and of the height of a dipole above the phantom on the reflection coefficient is analyzed through measurements and simulations. The effect of the type of tissue on the reflection coefficient is also investigated by performing simulations for a range of relative permittivity and conductivity combinations spanning the whole range of human tissues at 2.4 GHz. A semiempirical path loss model, validated by measurements and simulations, is presented for wireless communication, for antenna heights from 2 mm up to 5 cm and antenna separations from 10 to 50 cm. Also, the influence of the relative permittivity and conductivity on the path loss is modeled, leading to a range of possible values and lower and upper boundaries for the path loss as a function of the antenna height. The combination of the range with the boundaries results in a best-case and worst-case path loss model for wireless body area networks. The models are validated with measurements on the torso of a human.     

Regressor selection with the analysis of variance method

Identification of non-linear dynamical models of a black box nature involves both structure decisions, i.e., which regressors to use, the selection of a regressor function, and the estimation of the parameters involved. The typical approach in system identification seems to be to mix all these steps, which for example means that the selection of regressors is based on the fits that is achieved for different choices. Alternatively one could then interpret the regressor selection as based on hypothesis tests (F-tests) at a certain confidence level that depends on the data. It would in many cases be desirable to decide which regressors to use independently of the other steps.In this paper we investigate what the well-known method of analysis of variance (ANOVA) can offer for this problem. System identification applications violate many of the ideal conditions for which ANOVA was designed and we study how the method performs under such non-ideal conditions.ANOVA is much faster than a typical parametric estimation method, using e.g. neural networks. It is actually also more reliable, in our tests, in picking the correct structure even under non-ideal conditions. One reason for this may be that ANOVA requires the data set to be balanced, that is, all parts of the regressor space are weighted equally. Just applying tests of fit for the recorded data may give, for structure identification, improper weight to areas with many, or few, samples.     

Organizing for Continuous Innovation: On the Sustainability of Ambidextrous Organizations

Organizing for innovation does not present itself as a straightforward exercise. The complexities entailed when implementing an innovation strategy can be related directly to the multitude of objectives it comprises. Recently, several scholars have advanced the notions of semi‐ or quasi‐structures and ambidextrous organizations to handle these multiple requirements. These organizational forms imply the simultaneous presence of different activities, exhibiting differences in technology and market maturation. As a consequence, financial returns will reflect this diversified resource allocation pattern. Moreover, as higher levels of complexity are being introduced; ambidextrous organizations will encounter additional, organizational, costs. Compared to organizations that focus on the most profitable part of the portfolio, ambidextrous organizations – ceteris paribus – tend to be inferior in terms of financial returns. Within this contribution we explore under which conditions ambidextrous organizations can outperform focused firms; considered a prerequisite for their sustainability. In order to do so, we develop an analytical framework depicting the differential value dynamics, focused and ambidextrous firms can enact. Our findings reveal the relevancy of adopting extended time frames as well as introducing interface management practices aimed at cross‐fertilization. Finally, the synergetic potential of (underlying) technologies comes to the forefront as necessary in order for ambidextrous organizations to become sustainable.     

Visualising things. Perspectives on how to make things public through visualisation

In this paper, we will be discussing how visualisations can facilitate participatory processes by way of conveying issues of public concern as ‘things’. In the line of Latour’s plea to ‘make things public’, visualisations can be purposefully designed to trigger and encourage public debates concerning a wide range of issues. For this, we explore how a visualisation can be both transparent (i.e. visualising the complex entanglement of backstories of an issue) and readable. Specifically, we clarify the aspect of designing a readable visualisation of ‘things’. First, drawing from different fields of literature (i.e. Information Visualisation, Science and Technology Studies and Human-Computer-Interaction) we will articulate three main aspects of readability: engaging people to interact with a visualisation of complex issues, supporting sense making and encouraging reflection. Then, based on three empirical case studies, we indicate different design considerations in terms of engaging people to interact with a visualisation: contextualising a visualisation (via its location or medium), staging interaction and allowing people to provide their own perspective on the issue displayed. As a conclusion we propose a scenario that allows the visualisation to gradually become more transparent in support of its readability.     

Proposed Framework for Evaluating Quality of Experience in a Mobile,Testbed-oriented Living Lab Setting

The framework presented in this paper enables the evaluation of Quality of Experience (QoE) in a mobile, testbed-oriented Living Lab setting. As a result, it fits within the shift towards more user-centric approaches in innovation research and aims to bridge the gap between technical parameters and human experience factors. In view of this, Quality of Experience is seen as a multi-dimensional concept, which should be considered from an interdisciplinary perspective. Although several approaches for evaluating perceived QoE have been proposed in the past, they tend to focus on a limited number of objective dimensions and fail to grasp the subjective counterparts of users’ experiences. We therefore propose a distributed architecture for monitoring network Quality of Service (QoS), context information and subjective user experience based on the functional requirements related to real-time experience measurements in real-life settings. This approach allows us to evaluate all relevant QoE-dimensions in a mobile context.